Polynucleotide sequence relatedness among three groups of pathogenic Escherichia coli strains.

  title={Polynucleotide sequence relatedness among three groups of pathogenic Escherichia coli strains.},
  author={Don J. Brenner and G. Richard Fanning and Arnold G. Steigerwalt and Ida Orskov and Frits Orskov},
  journal={Infection and immunity},
  volume={6 3},
Escherichia coli strains that cause dysentery-like disease, parenteral infection, and infantile diarrhea form specific groups based on mobility of O and K antigens in immunoelectrophoresis. Members from each of these groups were assayed for gross nucleotide sequence relatedness. The method used was interspecific deoxyribonucleic acid (DNA) reassociation reactions carried out free in solution. Reassociated DNA was separated from unreacted DNA by passage through hydroxyapatite. DNA relatedness… CONTINUE READING
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