Polynucleotide recognition and degradation by bleomycin.

  title={Polynucleotide recognition and degradation by bleomycin.},
  author={S. Kane and S. Hecht},
  journal={Progress in nucleic acid research and molecular biology},
  • S. Kane, S. Hecht
  • Published 1994
  • Biology, Medicine
  • Progress in nucleic acid research and molecular biology
  • Publisher Summary This chapter discusses the chemistry of nucleic acid degradation, deoxyribonucleic acid (DNA) sequence and structure recognition, and the mode of DNA and ribonucleic acid (RNA) interaction, with bleomycin. The finding that a natural product, bleomycin, can recognize specific DNA sequences and mediate the oxidative destruction of the deoxyribose moiety of DNA in a manner that ultimately leads to strand scission has made it the prototype for the design of simple molecular… CONTINUE READING
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