Polynucleotide phosphorylase plays an important role in the generation of spontaneous mutations in Escherichia coli.

@article{Becket2012PolynucleotidePP,
  title={Polynucleotide phosphorylase plays an important role in the generation of spontaneous mutations in Escherichia coli.},
  author={Elinne Becket and Lawrence Tse and Madeline Yung and Alexander B. Cosico and J. H. Miller},
  journal={Journal of bacteriology},
  year={2012},
  volume={194 20},
  pages={5613-20}
}
Polynucleotide phosphorylase (PNP) plays a central role in RNA degradation, generating a pool of ribonucleoside diphosphates (rNDPs) that can be converted to deoxyribonucleoside diphosphates (dNDPs) by ribonucleotide reductase. We report here that spontaneous mutations resulting from replication errors, which are normally repaired by the mismatch repair… CONTINUE READING
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