Polyneuropathy following vincristine therapy in two patients with Charcot-Marie-Tooth syndrome.

@article{HoganDann1984PolyneuropathyFV,
  title={Polyneuropathy following vincristine therapy in two patients with Charcot-Marie-Tooth syndrome.},
  author={C M Hogan-Dann and W G Fellmeth and Stephen A. McGuire and V A Kiley},
  journal={JAMA},
  year={1984},
  volume={252 20},
  pages={
          2862-3
        }
}
The neurotoxicity of vincristine sulfate, a commonly used antineoplastic agent, has been well described. A literature review failed to reveal any absolute contraindications to the initial use of vincristine. We describe two patients with nodular sclerosing Hodgkin's disease in whom a rapidly progressive, but reversible, severe polyneuropathy developed when they were given a total of 4 mg of vincristine sulfate. Each was later shown to have the demyelinating form of Charcot-Marie-Tooth syndrome… CONTINUE READING