Polymyxin-B stimulates tumor necrosis factor-alpha production by human peripheral blood mononuclear cells.

@article{Jaber1998PolymyxinBST,
  title={Polymyxin-B stimulates tumor necrosis factor-alpha production by human peripheral blood mononuclear cells.},
  author={Bertrand L. Jaber and S Kalyan Sundaram and Miguel Cendoroglo Neto and Andrew J. King and Brian J. G. Pereira},
  journal={The International journal of artificial organs},
  year={1998},
  volume={21 5},
  pages={269-73}
}
Gram-negative bacterial lipopolysaccharide (LPS) is a well known stimulus for cytokine production, particularly interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha). Polymyxin B (PMX-B) is a cationic polypeptide that binds to LPS, neutralizing its biological effects. PMX-B also disrupts gram-negative bacterial cell membrane phospholipids but is highly toxic to mammalian cells, therefore is of limited use. PMX-B is used as additive to media, as a way to handle LPS contamination. To… CONTINUE READING