Polymyxin B resistance and biofilm formation in Vibrio cholerae are controlled by the response regulator CarR.

@article{Bilecen2015PolymyxinBR,
  title={Polymyxin B resistance and biofilm formation in Vibrio cholerae are controlled by the response regulator CarR.},
  author={Kivanc Bilecen and Jiunn Cn Fong and Andrew Tai-Ann Cheng and Christopher J. H. Jones and David S. Zamorano-S{\'a}nchez and Fitnat H. Yildiz},
  journal={Infection and immunity},
  year={2015},
  volume={83 3},
  pages={1199-209}
}
Two-component systems play important roles in the physiology of many bacterial pathogens. Vibrio cholerae's CarRS two-component regulatory system negatively regulates expression of vps (Vibrio polysaccharide) genes and biofilm formation. In this study, we report that CarR confers polymyxin B resistance by positively regulating expression of the almEFG genes… CONTINUE READING