Polymyxin B protects horses against induced endotoxaemia in vivo.

  title={Polymyxin B protects horses against induced endotoxaemia in vivo.},
  author={M. H. Barton and Anna K Parviainen and Natalie N Norton},
  journal={Equine veterinary journal},
  volume={36 5},
REASONS FOR PERFORMING STUDY A safe, affordable and effective treatment for endotoxaemia in horses is needed in order to reduce the incidence of this potentially fatal condition. OBJECTIVE To evaluate the effect of polymyxin B (PMB) on signs of experimentally-induced endotoxaemia. HYPOTHESIS PMB ameliorates the adverse effects of endotoxaemia without causing nephrotoxicity. METHODS Four groups of 6 healthy mature horses each received 20 ng endotoxin/kg bwt i.v. over 30 mins. Additionally… CONTINUE READING