Polymyxin B inhibits insulin-induced glucose transporter and IGF II receptor translocation in isolated adipocytes.

Abstract

In isolated adipocytes, polymyxin B inhibited insulin-induced glucose incorporation into lipids in a dose-dependent manner, while polymyxin E, a structurally related antibiotic, was ineffective. To approach the mechanism of this effect, the subcellular distribution of the glucose transporter Glut 4 was investigated. Adipocytes were pretreated without or… (More)

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