Polymyxin B in Combination with Antimicrobials Lacking In Vitro Activity versus Polymyxin B in Monotherapy in Critically Ill Patients with Acinetobacter baumannii or Pseudomonas aeruginosa Infections.

@article{Rigatto2015PolymyxinBI,
  title={Polymyxin B in Combination with Antimicrobials Lacking In Vitro Activity versus Polymyxin B in Monotherapy in Critically Ill Patients with Acinetobacter baumannii or Pseudomonas aeruginosa Infections.},
  author={Maria Helena Rigatto and Fabiane Jamono Vieira and Laura C Antochevis and Tain{\'a} F Behle and Natane T Lopes and Alexandre Prehn Zavascki},
  journal={Antimicrobial agents and chemotherapy},
  year={2015},
  volume={59 10},
  pages={6575-80}
}
There is no clinical evidence supporting the use of polymyxin B in combination with another antimicrobial for infections caused by extensively drug-resistant Acinetobacter baumannii or Pseudomonas aeruginosa isolates. We developed a cohort study of patients in two intensive care units from teaching hospitals to evaluate treatment with intravenous polymyxin B for ≥48 h for severe A. baumannii or P. aeruginosa infections. Covariates potentially associated with 30-day mortality were evaluated in a… CONTINUE READING
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