Polymyxin B as Adjuvant Therapy for Overwhelming Gram-negative Bacterial Sepsis

Abstract

Polymyxin B (PMB) is a surface-active agent and antibiotic which ameliorates the adverse effects of endotoxin. Sodium deoxycholate (NaD), a surface-active agent present in bile, also protects against endotoxin. To determine if either of these agents is efficacious in Gram-negative bacterial sepsis compared to antibiotics alone, 36 New Zealand White rabbits… (More)
DOI: 10.1203/00006450-198704010-00943

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