Polymyxin B-Immobilized Fiber Column Hemoperfusion Therapy for Septic Shock

@article{Mitaka2011PolymyxinBF,
  title={Polymyxin B-Immobilized Fiber Column Hemoperfusion Therapy for Septic Shock},
  author={Chieko Mitaka and Makoto Tomita},
  journal={Shock},
  year={2011},
  volume={36},
  pages={332-338}
}
Endotoxin, an outer membrane component of gram-negative bacteria, plays an important role in the pathogenesis of septic shock. Endotoxin adsorption therapy by polymyxin B-immobilized fiber column hemoperfusion (PMX) has been used for the treatment of septic shock patients in Japan since 1994. The covalent binding of polymyxin B onto the surface of the polystyrene-based carrier fiber in PMX inactivates the endotoxin in the blood without exerting toxicity. This study was performed as a systematic… 

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  • 2014
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Polymyxin B hemoperfusion improveshemodynamic status in patients withsepsis with both gram-negative and nongram-negative bacteria

PMX therapy is effective to improve hemodynamic status of septic patients not only with gram-negative but with non-gram-negative bacteria, and there is no significant deference between these groups.
...

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