Polymorphonuclear leukocyte-platelet interaction: role of P-selectin in thromboxane B2 and leukotriene C4 cooperative synthesis.

@article{Maugeri1994PolymorphonuclearLI,
  title={Polymorphonuclear leukocyte-platelet interaction: role of P-selectin in thromboxane B2 and leukotriene C4 cooperative synthesis.},
  author={Norma Maugeri and Virgilio Evangelista and Antonio Celardo and Giuseppe Dell'elba and Nicola Martelli and Paola Piccardoni and Giovanni de Gaetano and C. Cerletti},
  journal={Thrombosis and haemostasis},
  year={1994},
  volume={72 3},
  pages={450-6}
}
In PMN/platelet suspensions stimulated by fMLP giant mixed aggregates are formed and TxB2 and LTC4 are synthesized as the result of the cooperation in the arachidonic acid (AA) metabolism during cell/cell contact. PMN-derived cathepsin G induced the expression of P-selectin on platelet surface. GE12, an antibody against P-selectin, significantly reduced mixed cell aggregates. GE12 did not affect platelet aggregation induced by PMN-derived supernatants, indicating that the inhibitory effect of… CONTINUE READING