Polymorphonuclear leukocyte integrin profile in diabetes mellitus.

  title={Polymorphonuclear leukocyte integrin profile in diabetes mellitus.},
  author={Gregorio Caimi and Maria Montana and Roberto Citarrella and Ferdinando Porretto and A. Fede Catania and R Lo presti},
  journal={Clinical hemorheology and microcirculation},
  volume={27 2},
We examined the polymorphonuclear leukocyte (PMN) integrin pattern in 45 diabetic subjects without macrovascular complications, including 21 subjects with type 1 and 24 with type 2 diabetes mellitus. The PMN adhesion molecules (CD11a, CD11b, CD11c, CD18) were evaluated using indirect immunofluorescence and a flow cytometer, at baseline and after in vitro activation with 4-phorbol 12-myristate 13-acetate (PMA) and N-formyl-methionyl-leucyl-phenyl-alanine (fMLP). At baseline, in diabetic subjects… CONTINUE READING

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