Polymorphonuclear leukocyte chemiluminescence induced by formylmethionyl-leucyl-phenylalanine and phorbol myristate acetate: Effects of catalase and superoxide dismutase

@article{Dahlgren1987PolymorphonuclearLC,
  title={Polymorphonuclear leukocyte chemiluminescence induced by formylmethionyl-leucyl-phenylalanine and phorbol myristate acetate: Effects of catalase and superoxide dismutase},
  author={Claes Dahlgren},
  journal={Agents and Actions},
  year={1987},
  volume={21},
  pages={104-112}
}
When polymorphonuclear leukocytes (PMNL) interact with the soluble stimuli FMLP or PMA, the cells increase their production of oxidative metabolites. This increased production can be measured as luminol amplified light emission or chemiluminescence (CL). The chemiluminescence of human PMNL has been investigated, and it was found that the chemoattractant FMLP induced a bimodal response with a sharp peak of activity within 1 min, and a second peak after around 5 min. In contrast, PMA induced a… CONTINUE READING

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