Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function

@article{Staiger2008PolymorphismsWT,
  title={Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function},
  author={Harald Staiger and Fausto Machicao and Silke A. Sch{\"a}fer and Kerstin Kirchhoff and Konstantinos Kantartzis and Martina Guthoff and Guenther Silbernagel and Norbert Stefan and Hans-Ulrich H{\"a}ring and Andreas Fritsche},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={881 - 885}
}
BACKGROUND Very recently, a novel type 2 diabetes risk gene, i.e., MTNR1B, was identified and reported to affect fasting glycemia. Using our thoroughly phenotyped cohort of subjects at an increased risk for type 2 diabetes, we assessed the association of common genetic variation within the MTNR1B locus with obesity and prediabetes traits, namely impaired insulin secretion and insulin resistance. METHODOLOGY/PRINCIPAL FINDINGS We genotyped 1,578 non-diabetic subjects, metabolically… CONTINUE READING

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