Polymorphisms predicted to alter function in prostaglandin E2 synthase and prostaglandin E2 receptors.

@article{Bigler2007PolymorphismsPT,
  title={Polymorphisms predicted to alter function in prostaglandin E2 synthase and prostaglandin E2 receptors.},
  author={Jeannette Bigler and Justin G Sibert and Elizabeth M Poole and Christopher S Carlson and John D. Potter and Cornelia M Ulrich},
  journal={Pharmacogenetics and genomics},
  year={2007},
  volume={17 3},
  pages={221-7}
}
BACKGROUND AND OBJECTIVE Prostaglandin synthesis is the primary target of aspirin and other nonsteroidal antiinflammatory drugs, and thus is a pathway of major interest to pharmacology, pharmacogenetics, and epidemiology. Several lines of evidence implicate prostaglandin E2 in carcinogenesis; this study aimed to identify genetic variants in genes related to prostaglandin E2 synthesis and signaling. METHODS We resequenced the coding regions of human prostaglandin E2 synthase (PGES), and… CONTINUE READING