Polymorphisms of toll-like receptor 2 and 4 genes in Chagas disease.

  title={Polymorphisms of toll-like receptor 2 and 4 genes in Chagas disease.},
  author={German A Zafra and Oscar W. M{\'a}rquez Fl{\'o}rez and Carlos A. Morillo and Luis Eduardo Echeverria and Javier Mart{\'i}n and Clara I. Gonzalez},
  journal={Memorias do Instituto Oswaldo Cruz},
  volume={103 1},
The aim of this study was to test the possible implication of toll-like receptor 2 (TLR2) and TLR4 gene polymorphisms in determining the susceptibility to Chagas' disease. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism in 475 individuals from Colombia, 143 seropositive with chagasic cardiomyopathy, 132 seropositive asymptomatic and 200 seronegative. The TLR2 arginine to glutamine substitution at residue 753(Arg753Gln) polymorphism was absent in… CONTINUE READING