Polymorphisms of the toll-like receptor 2 and 4 genes are associated with faster progression and a more severe course of sepsis in critically ill patients
@article{Nachtigall2014PolymorphismsOT, title={Polymorphisms of the toll-like receptor 2 and 4 genes are associated with faster progression and a more severe course of sepsis in critically ill patients}, author={Irit Nachtigall and Andrey Tamarkin and Sascha Tafelski and Andreas Weimann and Andreas Rothbart and Susanne Heim and Klaus Wernecke and Claudia D. Spies}, journal={Journal of International Medical Research}, year={2014}, volume={42}, pages={110 - 93} }
Objective To determine whether the Arg753Gln polymorphism of the toll-like receptor 2 (TLR2) gene and the Asp299Gly polymorphism of the TLR4 gene in critically ill patients affect their clinical outcomes. Methods Medical and surgical patients in three intensive care units (ICU) were enrolled in this prospective study. TLR2 and TLR4 gene polymorphisms were determined using restriction fragment length polymorphism analysis. Results A total of 145 patients were included in this study: 28 patients…
37 Citations
Role of Toll-Like Receptors 2 and 4 Genes Polymorphisms in Neonatal Sepsis in a Developing Country: A Pilot Study
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It is suggested that any polymorphisms in TLR2 and TLR4 might have a role that interferes with the innate immune response of newborn.
Polymorphisms of Toll-like receptors (TLR2 and TLR4) are associated with the risk of infectious complications in acute myeloid leukemia
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To the best knowledge, this study represents the first analysis demonstrating that polymorphisms of TLR2 and TLR4 influence the risk of infectious complications in patients with AML undergoing induction chemotherapy.
Investigation of TLR2 and TLR4 Polymorphisms and Sepsis Susceptibility: Computational and Experimental Approaches
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The results conclude that the TLR2 genotype may be a risk factor for sepsis in adult patients.
TOLL LIKE RECEPTOR TYPE FOUR GENE POLYMORPHISM IN NEONATAL SEPSIS IN ZAGAZIG UNIVERSITY CHILDREN’S HOSPITAL
- MedicineZagazig University Medical Journal
- 2019
This study found no statistically significant association between TLR4 Asp299Gly gene polymorphism and severity of neonatal sepsis and single nucleotide polymorphisms among various TLR genes may be related to susceptibility/resistance to certain infections and other inflammatory diseases.
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Gene polymorphisms and febrile neutropenia in acute leukemia--no association with IL-4, CCR-5, IL-1RA, but the MBL-2, ACE, and TLR-4 are associated with the disease in Turkish patients: a preliminary study.
- Biology, MedicineGenetic testing and molecular biomarkers
- 2014
TLR-4, ACE, and MBL-2 genes might play roles in the genetic etiopathogenesis of FN in patients with ALs, according to this first study to evaluate their roles in febrile neutropenia resulting from chemotherapy.
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- Biology, MedicineAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica
- 2017
Examination of SNPs in the genes encoding TLR2 and TOLLIP found that these polymorphisms were not associated with susceptibility to SABSI, severity, 30‐day all‐cause mortality, orSABSI caused by the clonal complex 30 (CC30) genotype.
Association between the TLR2 Arg753Gln polymorphism and the risk of sepsis: a meta-analysis
- BiologyCritical Care
- 2015
The present meta-analysis supports a direct effect of the TLR2 Arg753Gln polymorphism on sepsis risk, especially in Europeans, and might be used as a relevant risk estimate for the development of sepsi.
Role of MBL2 Polymorphisms in Sepsis and Survival: A Pilot Study and In Silico Analysis
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This study may confirm the redundancy of MBL and the absence of significant impact on sepsis liability and mortality in adult patients and confirm the role of related genes’ polymorphism in predicting the liability to infection, sepsi, septic shock and survival.
Pathogenic variants in TIRAP and MyD88 are not associated withneonatal sepsis in a South Indian population.
- Medicine, Biology
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The genotypic and allelic frequencies of both the variants studied were found to be not associated with susceptibility to neonatal sepsis, however, the genotype AA was significantly associated with mechanical ventilation and high plasma CRP levels among the population studied.
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