Polymorphisms of the luteinizing hormone/chorionic gonadotropin receptor gene: association with maldescended testes and male infertility.

@article{Simoni2008PolymorphismsOT,
  title={Polymorphisms of the luteinizing hormone/chorionic gonadotropin receptor gene: association with maldescended testes and male infertility.},
  author={Manuela Simoni and F T{\"u}ttelmann and Caroline Michel and Yvonne B{\"o}ckenfeld and Eberhard Nieschlag and Joerg Gromoll},
  journal={Pharmacogenetics and genomics},
  year={2008},
  volume={18 3},
  pages={193-200}
}
OBJECTIVE Maldescended testes are the most common genital anomaly in newborns and are associated with testicular malignancy and infertility. As the inguinoscrotal phase of testis descent is androgen-dependent and requires integrity of the luteinizing hormone/chorionic gonadotropin receptor (LHCGR), we investigated whether nonsynonymous polymorphisms of the LHCGR gene are associated with maldescended testes. METHODS This was a retrospective case-control study including 278 patients with… CONTINUE READING

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