Polymorphisms of the human prolactin gene--implications for production of lymphocyte prolactin and systemic lupus erythematosus.

@article{Stevens2001PolymorphismsOT,
  title={Polymorphisms of the human prolactin gene--implications for production of lymphocyte prolactin and systemic lupus erythematosus.},
  author={Adam Stevens and David W Ray and Jane Worthington and Julian R. E. Davis},
  journal={Lupus},
  year={2001},
  volume={10 10},
  pages={676-83}
}
Hyperprolactinaemia is associated with systemic lupus erythematosus (SLE) but the mechanism is unknown. Prolactin is expressed not only by pituitary lactotrophic cells but also by T-lymphocytes under the control of an alternative upstream promoter region. T-lymphocytes from SLE patients have been shown to secrete more prolactin than controls, thus implying a possible underlying difference in regulation. This may be due to genetic polymorphism that can be determined by scanning for mutations and… CONTINUE READING
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