Polymorphisms of the estrogen-metabolizing genes CYP17 and catechol-O-methyltransferase and risk of epithelial ovarian cancer.

@article{Garner2002PolymorphismsOT,
  title={Polymorphisms of the estrogen-metabolizing genes CYP17 and catechol-O-methyltransferase and risk of epithelial ovarian cancer.},
  author={Elizabeth I. O. Garner and Erika E Stokes and Ross S Berkowitz and S. C. Mok and Daniel W Cramer},
  journal={Cancer research},
  year={2002},
  volume={62 11},
  pages={3058-62}
}
Because some studies have linked polymorphic variants of the estrogen-metabolizing genes CYP17 and catechol O-methyl transferase (COMT) with risk for hormonally related cancers, we sought to determine whether selected polymorphisms of these genes differed between women with and without ovarian cancer. From a population-based study of ovarian cancer, we analyzed DNA from a total of 480 cases and controls. PCR amplification was performed using primers that amplify restriction sites for MspAI (A2… CONTINUE READING
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