Polymorphisms of the beta1-adrenergic receptor gene are associated with essential hypertension in Chinese.

@article{Peng2009PolymorphismsOT,
  title={Polymorphisms of the beta1-adrenergic receptor gene are associated with essential hypertension in Chinese.},
  author={Yingxin Peng and Hao Xue and Leiming Luo and Wenjing Yao and Rongbin Li},
  journal={Clinical chemistry and laboratory medicine},
  year={2009},
  volume={47 10},
  pages={1227-31}
}
BACKGROUND The beta1-adrenergic receptor (ADRB1) plays a pivotal role in mediating signal transduction of the sympathetic-adrenal system, which is involved in the regulation of cardiac output and peripheral resistance. Our goal was to determine whether the polymorphisms Arg389Gly (rs1801253) and Ser49Gly (rs1801252) of the ADRB1 gene were associated with essential hypertension in Chinese. METHODS We tested our hypothesis in two independent case-control studies, one comprised 481 patients with… CONTINUE READING
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