Polymorphisms of the IL-1 gene complex are associated with alcohol dependence in Spanish Caucasians: data from an association study.

@article{Siz2009PolymorphismsOT,
  title={Polymorphisms of the IL-1 gene complex are associated with alcohol dependence in Spanish Caucasians: data from an association study.},
  author={Pilar Alejandra S{\'a}iz and M P Garcia-Portilla and Gerardo Fl{\'o}rez and P Corcoran and Celso Arango and Blanca Morales and Juan Carlos Leza and Sandra Reyes {\'A}lvarez and Eva Maria D{\'i}az and V. Gonz{\'a}lez {\'A}lvarez and E. Coto and Luis Nogue{\'i}ras and Julio Bobes},
  journal={Alcoholism, clinical and experimental research},
  year={2009},
  volume={33 12},
  pages={2147-53}
}
BACKGROUND There is growing evidence for involvement of pro-inflammatory cytokines in alcohol dependence. The aim of this study was to investigate whether 4 functionally relevant polymorphisms of the interleukin-1 (IL-1) and tumor necrosis factor-alpha genes were associated with alcohol dependence and with measures of clinical severity and treatment outcome. METHODS Two hundred alcohol-dependent (AD) patients and 420 healthy controls from the same Spanish Caucasian population were genotyped… CONTINUE READING