Polymorphisms of the DNA repair genes XRCC1, XRCC3, XPD, interaction with environmental exposures, and bladder cancer risk in a case-control study in northern Italy.

@article{Shen2003PolymorphismsOT,
  title={Polymorphisms of the DNA repair genes XRCC1, XRCC3, XPD, interaction with environmental exposures, and bladder cancer risk in a case-control study in northern Italy.},
  author={Min Shen and Rayjean J Hung and Paul Brennan and Christian Malaveille and Francesco Di Donato and Donatella Placidi and Angela Carta and Agn{\`e}s H Hautefeuille and Paolo Boffetta and Stefano Porru},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2003},
  volume={12 11 Pt 1},
  pages={1234-40}
}
Tobacco smoking and occupational exposures are the main known risk factors for bladder cancer, causing direct and indirect damage to DNA. Repair of DNA damage is under genetic control, and DNA repair genes may play a key role in maintaining genome integrity and preventing cancer development. Polymorphisms in DNA repair genes resulting in variation of DNA repair efficiency may therefore be associated with bladder cancer risk. A hospital-based case-control study was conducted in Brescia, Italy… CONTINUE READING

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