Polymorphisms of the CYP1B1 gene may be associated with the onset of natural menopause in Chinese women.

@article{Long2006PolymorphismsOT,
  title={Polymorphisms of the CYP1B1 gene may be associated with the onset of natural menopause in Chinese women.},
  author={Jirong Long and Xiao-ou Shu and Qiuyin Cai and Hui Cai and Yu-tang Gao and Fan Jin and Wei Zheng},
  journal={Maturitas},
  year={2006},
  volume={55 3},
  pages={238-46}
}
The Cytochrome P450 1B1 (CYP1B1) is one of the major CYP450 enzymes catalyzing 4-hydroxylation, an important elimination step for estrogens. Relatively little is known, however, about the impact of this gene on the onset and cessation of menstruation, which are significant milestones in a woman's life and predictors of many hormone related diseases. In this report, we described the association of four SNPs in the CYP1B1 gene, Arg48Gly, Ala119Ser, Leu432Val, and Asp449Asp, with the ages of… CONTINUE READING

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