Polymorphisms of the BRAF gene predispose males to malignant melanoma

  title={Polymorphisms of the BRAF gene predispose males to malignant melanoma},
  author={Peter William Meyer and Consolato M Sergi and Claus Garbe},
  journal={Journal of Carcinogenesis},
  pages={7 - 7}
The incidence of malignant melanoma has rapidly increased in recent years. Evidence points to the role of inheritance in melanoma development, but specific genetic risk factors are not well understood. Recent reports indicate a high prevalence of somatic mutations of the BRAF gene in melanomas and melanocytic nevi. Here we report that germ-line single nucleotide polymorphisms (SNPs) in BRAF are significantly associated with melanoma in German males, but not females. At-risk haplotypes of BRAF… CONTINUE READING

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