Polymorphisms of p16, p27, p73, and MDM2 Modulate Response and Survival of Pancreatic Cancer Patients Treated with Preoperative Chemoradiation

@article{Chen2008PolymorphismsOP,
  title={Polymorphisms of p16, p27, p73, and MDM2 Modulate Response and Survival of Pancreatic Cancer Patients Treated with Preoperative Chemoradiation},
  author={Jinyun Chen and Dong-hui Li and Ann M. Killary and Subrata Sen and Christopher I. Amos and Douglas B. Evans and James L Abbruzzese and Marsha L. Frazier},
  journal={Annals of Surgical Oncology},
  year={2008},
  volume={16},
  pages={431-439}
}
Genetic polymorphisms play an important role in clinical response to cytotoxic therapies. We hypothesized that polymorphisms in cell cycle genes may modulate response to preoperative chemoradiation and survival of pancreatic cancer patients. We evaluated 12 single-nucleotide polymorphisms (SNPs) of ten cell cycle genes in 88 patients with resectable adenocarcinoma of the pancreatic head who were treated with neoadjuvant concurrent gemcitabine and radiotherapy. Response was assessed by… CONTINUE READING
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