Polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and thymidylate synthase (TYMS) in multiple myeloma risk.

@article{Lima2008PolymorphismsOM,
  title={Polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and thymidylate synthase (TYMS) in multiple myeloma risk.},
  author={Carmen S P Lima and Manoela Marques Ortega and Margareth Castro Ozelo and Renato C Araujo and C{\'a}rmino Ant{\^o}nio de Souza and Irene GH Lorand-Metze and Joyce Maria Annichino-Bizzacchi and Fernando Ferreira Costa},
  journal={Leukemia research},
  year={2008},
  volume={32 3},
  pages={401-5}
}
We tested whether the polymorphisms of the methylenetetrahydrofolate reductase gene, MTHFR C677T and A1298C, the methionine synthase gene, MTR A2756G, the methionine synthase reductase gene, MTRR A66G, and the thymidylate synthase gene, TYMS 2R-->3R, involved in folate and methionine metabolism, altered the risk for multiple myeloma (MM). Genomic DNA from 123MM patients and 188 controls was analysed by polymerase chain reaction and restriction digestion for the polymorphism analyses. The… CONTINUE READING

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