Polymorphisms of innate immunity genes and susceptibility to lymphatic filariasis

@article{Hise2003PolymorphismsOI,
  title={Polymorphisms of innate immunity genes and susceptibility to lymphatic filariasis},
  author={Amy G Hise and Fred E Hazlett and Moses John Bockarie and Peter A Zimmerman and Daniel J. Tisch and James W. Kazura},
  journal={Genes and Immunity},
  year={2003},
  volume={4},
  pages={524-527}
}
We examined 906 residents of an area of Papua New Guinea where bancroftian filariasis is endemic for genetic polymorphisms in three innate immunity genes suspected of contributing to susceptibility to infection and lymphatic pathology. Active infection was confirmed by the presence of blood-borne microfilariae and circulating filarial antigen in plasma. Disease was ascertained by physical examination for the presence of overt lymphedema (severe swelling of an arm or leg) or hydrocele. There was… CONTINUE READING

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