Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer.

@article{Kiss2004PolymorphismsOG,
  title={Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer.},
  author={Istv{\'a}n Kiss and Arp{\'a}d N{\'e}meth and Barna Bogner and G{\'a}bor Pajkos and Zsuzsa Ors{\'o}s and J{\'a}nos S{\'a}ndor and Andr{\'a}s Csejtey and Zsolt Faluhelyi and Imre Rodler and Istvan A Ember},
  journal={Anticancer research},
  year={2004},
  volume={24 6},
  pages={3965-70}
}
BACKGROUND Glutathione-S-transferases (GSTs) and N-acetyltransferases (NATs) are involved in the metabolism of a wide range of carcinogenic chemicals. Allelic polymorphism of these enzymes is associated with variations in enzyme activity, hence it may affect the concentration of activated carcinogenic chemicals in the body. Previous studies suggest a possible cancer risk-modifying effect of these allelic polymorphisms, but the results are still controversial. We evaluated the effect of GSTM1… CONTINUE READING