Polymorphisms of genes related to phase-I metabolic enzymes affecting the clinical efficacy and safety of clopidogrel treatment

@article{Alkattan2021PolymorphismsOG,
  title={Polymorphisms of genes related to phase-I metabolic enzymes affecting the clinical efficacy and safety of clopidogrel treatment},
  author={Abdullah N. Alkattan and Eman Alsalameen},
  journal={Expert Opinion on Drug Metabolism \& Toxicology},
  year={2021},
  volume={17},
  pages={685 - 695}
}
ABSTRACT Introduction: Clopidogrel is an antiplatelet medication described as a prodrug, which cannot exert the antiplatelet effect until being biotransformed to the active metabolite. It is commonly used to reduce the risk of blood coagulation in patients diagnosed with acute coronary syndrome, or ischemic stroke. Area covered: We reviewed published articles in PubMed and Google Scholar that focused on the mutations of CYP2C19, CYP3A4, CYP2C9, CYP2B6, and CYP1A2 genes related to clopidogrel… 
1 Citations
The role of CYP2C19 gene polymorphisms on antiplatelet activity of clopidogrel among Arabs: systematic review and meta-analysis
TLDR
It is revealed that Arabs carrying CYP2C19*2 and CYP19*3 alleles may not respond to clopidogrel and may put those patients at risk of recurrent CVEs and did not showed a significant role either in increase or decrease the antiplatelet efficacy of clopIDogrel.

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TLDR
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