Polymorphisms of genes involved in the hypoxia signaling pathway and the development of abdominal aortic aneurysms or large-artery atherosclerosis.

@article{Strauss2015PolymorphismsOG,
  title={Polymorphisms of genes involved in the hypoxia signaling pathway and the development of abdominal aortic aneurysms or large-artery atherosclerosis.},
  author={Ewa Strauss and Krzysztof Waliszewski and G. Oszkinis and Ryszard Staniszewski},
  journal={Journal of vascular surgery},
  year={2015},
  volume={61 5},
  pages={1105-13.e3}
}
BACKGROUND The pathogenesis of aortic diseases, both aneurysmal and occlusive, is associated with the occurrence of local ischemic/hypoxic conditions, but the genetic factors that differentiate the predisposition to specific types of aortic diseases are largely unknown. In this study, the functional variants in genes involved in the hypoxia signaling pathway, hypoxia-inducible factor-1α (HIF1A) 1772C>T, 1790G>A, and vascular endothelial growth factor (VEGFA) -634G>C, were analyzed in search of… CONTINUE READING