Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European Prospective Investigation into Cancer-Eurgast cohort.

@article{Companioni2014PolymorphismsOH,
  title={Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European Prospective Investigation into Cancer-Eurgast cohort.},
  author={Osmel Companioni and Catalina Bonet and Xavier Mu{\~n}oz and Elisabete Weiderpass and Salavatore Panico and Rosario Tumino and Domenico Palli and Claudia Agnoli and Paolo Vineis and Marie-Christine Boutron-Ruault and Antoine Racine and Francoise Clavel-Chapelon and Ruth C. Travis and Kay-tee Khaw and Elio Riboli and Neil Murphy and Anne-Claire Vergnaud and Antonia Trichopoulou and V Benetou and Dimitrios Trichopoulos and Eiliv Lund and Dorthe Johansen and Bj{\"o}rn Lindkvist and Mattias Johansson and Malin Sund and Eva Ardanaz and Emilio S{\'a}nchez-Cantalejo and Jos{\'e} Mar{\'i}a Huerta and Miren Dorronsoro and Jos{\'e} Ram{\'o}n Quir{\'o}s and Anne Tjonneland and Lotte Maxild Mortensen and Kim Overvad and Jenny Chang-Claude and Cosmeri Rizzato and Heiner Boeing and Hendrik B Bueno-de-Mesquita and Peter D Siersema and Petra H. M. Peeters and Mattijs E. Numans and F{\'a}tima Carneiro and Idlir Licaj and Heinz Freisling and N{\'u}ria Sala and Carlos Alberto Gonz{\'a}lez},
  journal={International journal of cancer},
  year={2014},
  volume={134 1},
  pages={
          92-101
        }
}
Helicobacter pylori is a recognized causal factor of noncardia gastric cancer (GC). Lipopolysaccharide and peptidoglycan of this bacterium are recognized by CD14, TLR4 and NOD2 human proteins, while NFKB1 activates the transcription of pro-inflammatory cytokines to elicit an immune response. Single nucleotide polymorphisms (SNPs) in these genes have been associated with GC in different populations. We genotyped 30 SNPs of these genes, in 365 gastric adenocarcinomas and 1,284 matched controls… CONTINUE READING

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