Polymorphisms of HLA-DR and -DQ genes in Japanese patients with bullous pemphigoid.

  title={Polymorphisms of HLA-DR and -DQ genes in Japanese patients with bullous pemphigoid.},
  author={Aiko Okazaki and Sachiko T Miyagawa and Yukio Yamashina and Wataru Kitamura and Toshikazu Shirai},
  journal={The Journal of dermatology},
  volume={27 3},
Bullous pemphigoid (BP), an autoimmune skin disease of the elderly, is mediated by autoantibodies that bind to hemidesmosomes of epidermal basal cells. This study investigated BP-associated HLA-DR and -DQ genes among Japanese patients. We analyzed HLA-DR and -DQ genes among 23 Japanese BP patients based on the polymerase chain reaction-restriction fragment length polymorphism. Eighteen of these 23 patients (78%) carried at least one allele of HLA-DRB1*04 or DRB1*1101, with significant increases… CONTINUE READING


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