Polymorphisms of DNA repair gene XRCC3 Thr241Met and risk of gastric cancer in a Chinese population.

@article{Shen2004PolymorphismsOD,
  title={Polymorphisms of DNA repair gene XRCC3 Thr241Met and risk of gastric cancer in a Chinese population.},
  author={Hongbing Shen and Xinru Wang and Zhibin Hu and Zhengdong Zhang and Yaochu Xu and Xu Shell Hu and Jiantao Guo and Qingyi Wei},
  journal={Cancer letters},
  year={2004},
  volume={206 1},
  pages={51-8}
}
Mammalian cells are constantly exposed to a wide variety of genotoxic agents from both endogenous and exogenous sources. Genetic variability in DNA repair may contribute to human cancer risk. In this population-based case-control study in China, we tested the hypothesis that a C to T variant (Thr241Met) of DNA repair gene XRCC3 (X-ray repair cross-complementing group 3) is associated with risk of developing gastric cancer. We genotyped for this variant using polymerase chain reaction… CONTINUE READING

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