Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.

@article{Kaisaki2004PolymorphismsIT,
  title={Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.},
  author={Pamela Jane Kaisaki and Marc D{\'e}l{\'e}pine and Peng Yeong Woon and Liam M Sebag-Montefiore and Steven P. Wilder and Stephan Menzel and Nathalie Vionnet and Evelyne Marion and J P Riveline and Guillaume Charpentier and St{\'e}phane Schurmans and Jonathan C Levy and Mark Lathrop and Martin Farrall and Dominique Gauguier},
  journal={Diabetes},
  year={2004},
  volume={53 7},
  pages={1900-4}
}
Type II SH2 domain-containing inositol 5-phosphatase (INPPL1, or SHIP2) plays an important role in the control of insulin sensitivity. INPPL1 mutations affecting gene function have been found in rat models of type 2 diabetes and hypertension and in type 2 diabetic patients. We investigated the influence of nucleotide variation in INPPL1 on components of the metabolic syndrome. Following comprehensive resequencing of the gene, we genotyped 12 informative polymorphisms in 1,304 individuals from… CONTINUE READING

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