Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk.

@article{Anantharaman2011PolymorphismsIT,
  title={Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk.},
  author={Devasena Anantharaman and Tanuja A Samant and Subrata Sen and Manoj B. Mahimkar},
  journal={Oral oncology},
  year={2011},
  volume={47 9},
  pages={
          866-72
        }
}
  • Devasena Anantharaman, Tanuja A Samant, +1 author Manoj B. Mahimkar
  • Published in Oral oncology 2011
  • Medicine
  • The highest rates of oral squamous cell carcinomas are observed in south Asia, particularly in India, where complex forms of tobacco and alcohol exposures exist. Genetic polymorphisms contribute significantly to observed differences in cancer susceptibility. We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco… CONTINUE READING

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