Polymorphisms in the tumor necrosis factor-alpha gene promoter may predispose to severe silicosis in black South African miners.

@article{Corbett2002PolymorphismsIT,
  title={Polymorphisms in the tumor necrosis factor-alpha gene promoter may predispose to severe silicosis in black South African miners.},
  author={Elizabeth Lucy Corbett and Nadine Mozzato-Chamay and Anthony E. Butterworth and Kevin M. De Cock and Brian G. Williams and Gavin John Churchyard and David J Conway},
  journal={American journal of respiratory and critical care medicine},
  year={2002},
  volume={165 5},
  pages={690-3}
}
Susceptibility to silicosis is in part genetically determined. Polymorphisms in the promoter region of tumor necrosis factor (TNF)-alpha, a cytokine with a central role in the pathophysiology of silicosis, have been associated with predisposition to several infectious and inflammatory diseases. Polymorphisms at positions -308, -238, and -376 in the TNF-alpha promoter region were compared in nine patients with severe silicosis with International Labour Office (ILO) grade 3 nodularity, 112… CONTINUE READING

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