Polymorphisms in the prostate-specific antigen gene promoter do not predict serum prostate-specific antigen levels in African-American men

@article{BeebeDimmer2006PolymorphismsIT,
  title={Polymorphisms in the prostate-specific antigen gene promoter do not predict serum prostate-specific antigen levels in African-American men},
  author={Jennifer L Beebe-Dimmer and Leslie A. Lange and Jason E. Cain and Robert Craig Lewis and Anna M. Ray and A. Venugopala Sarma and Ethan M. Lange and Kathleen A. Cooney},
  journal={Prostate Cancer and Prostatic Diseases},
  year={2006},
  volume={9},
  pages={50-55}
}
A major problem with the use of serum prostate-specific antigen (PSA) in predicting prostate cancer risk is the considerable variability of such measurements. Cramer et al. identified a set of single-nucleotide polymorphisms (SNPs) in the upstream regulatory region of the PSA gene that were each associated with increased promoter activity and serum PSA, further suggesting that genotyping these SNPs could be useful in improving the predictive value of PSA screening. In order to replicate this… CONTINUE READING

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