Polymorphisms in the p53 pathway

  title={Polymorphisms in the p53 pathway},
  author={E Christine Pietsch and Olivier Humbey and Maureen E Murphy},
The p53 tumor suppressor gene continues to be distinguished as the most frequently mutated gene in human cancer; this gene can be found mutated in up to 50% of human tumors of diverse histological type. It is generally accepted that the ability of p53 to induce either growth arrest or programmed cell death in response to diverse stimuli underlies the powerful selection against this protein in the development of cancer. It is somewhat surprising, then, to find p53 and several target genes in… CONTINUE READING

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