Polymorphisms in the nitric oxide synthase 1 gene are associated with severe chronic rhinosinusitis.

@article{Zhang2011PolymorphismsIT,
  title={Polymorphisms in the nitric oxide synthase 1 gene are associated with severe chronic rhinosinusitis.},
  author={Yuan Zhang and Leandra Mfuna Endam and Abdelali Filali-Mouhim and Yohan Boss{\'e} and R Castano and Martin Y. Desrosiers},
  journal={American journal of rhinology & allergy},
  year={2011},
  volume={25 2},
  pages={e49-54}
}
BACKGROUND Nitric oxide (NO), is a biological messenger molecule and a component of innate immunity, with important roles in the regulation of inflammation and in defense against bacterial biofilms. Polymorphisms in genes regulating NO production have the potential for a role in the development of chronic rhinosinusitis (CRS). The purpose of this study was to determine whether polymorphisms in genes regulating NO synthesis are associated with CRS. METHODS An established population of 206… CONTINUE READING