Polymorphisms in the myocilin promoter unrelated to the risk and severity of primary open-angle glaucoma.

@article{Fan2004PolymorphismsIT,
  title={Polymorphisms in the myocilin promoter unrelated to the risk and severity of primary open-angle glaucoma.},
  author={Bao-jian Fan and Yuk-fai Leung and Chi-Pui Pang and Dorothy Shu Ping Fan and Dan-yi Wang and Wing-Chiu Tong and Pancy Oi Sin Tam and John Kien Han Chua and T Lau and Dennis Shun Chiu Lam},
  journal={Journal of glaucoma},
  year={2004},
  volume={13 5},
  pages={377-84}
}
PURPOSE To investigate the proximal 2.5 kb promoter in the myocilin (MYOC) gene for mutations in Chinese patients with primary open-angle glaucoma (POAG). PATIENTS AND METHODS We screened for sequence alterations in the MYOC promoter in 88 unrelated Chinese patients with POAG and 94 unrelated individuals without glaucoma, aged 50 years or above, as control subjects. In addition, the specific MYOC.mt1 polymorphism was determined in a total of 212 POAG patients and 221 control subjects. The… CONTINUE READING