Polymorphisms in the multidrug resistance-1 (MDR1) gene influence the response to atorvastatin treatment in a gender-specific manner.

@article{Kajinami2004PolymorphismsIT,
  title={Polymorphisms in the multidrug resistance-1 (MDR1) gene influence the response to atorvastatin treatment in a gender-specific manner.},
  author={Kouji Kajinami and Margaret Elizabeth Brousseau and Jos{\'e} M. Ordov{\'a}s and ErnstJ. Schaefer},
  journal={The American journal of cardiology},
  year={2004},
  volume={93 8},
  pages={
          1046-50
        }
}
To test the hypothesis that variations in the multidrug resistance-1 gene influence the response to statin treatment, 2 prevalent polymorphisms (G2677T/A and C3435T) were examined in 344 hypercholesterolemic patients treated with atorvastatin (10 mg). The C3435T polymorphism was significantly and independently associated with a smaller reduction in low-density lipoprotein cholesterol and with a larger increase in high-density lipoprotein cholesterol, relative to variant allele carriers, in a… CONTINUE READING
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