Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia.

@article{Endler2006PolymorphismsIT,
  title={Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia.},
  author={Georg Endler and Rodrig Marculescu and Philipp M. Starkl and Alexander Binder and Gotho Geishofer and Martin Mueller and Bettina Zoehrer and Bernhard Resch and Werner Zenz and Christine Mannhalter},
  journal={Clinical chemistry},
  year={2006},
  volume={52 3},
  pages={511-4}
}
BACKGROUND An association has been described between mortality in children with meningococcal disease and functional polymorphisms in the interleukin-1 (IL1) cluster. We undertook a multicenter study to evaluate associations of these polymorphisms in a Central European population. PATIENTS AND METHODS The study involved 95 Middle European pediatric hospitals. We collected blood samples from, and clinical information about, 285 previously healthy children with meningococcal infection. We used… CONTINUE READING

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