• DOI:10.1093/HUMREP/DEI205
Corpus ID: 15015374

Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls.

@article{Villuendas2005PolymorphismsIT,
  title={Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls.},
  author={G. Villuendas and J. Botella-Carretero and B. Rold{\'a}n and J. Sancho and H. Escobar-Morreale and J. S. San Mill{\'a}n},
  journal={Human reproduction},
  year={2005},
  volume={20 11},
  pages={
          3184-91
        }
}

• G. Villuendas, J. Botella-Carretero, +3 authors J. S. San Millán
• Published 2005
• Biology, Medicine
• Human reproduction

BACKGROUND We aimed to evaluate the influence of the Gly972Arg variant of the insulin receptor substrate-1 gene (IRS-1) and the Gly1057Asp variant in IRS-2 on insulin resistance and glucose tolerance in women with polycystic ovary syndrome (PCOS) and healthy controls. METHODS Genotypes, allelic frequencies, indexes of insulin resistance, glucose tolerance and hormone profiles were studied in a large sample of Spanish PCOS (n = 103) women compared with a control group (n = 48) of healthy women… Expand

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