Polymorphisms in the hypoxia inducible factor-1alpha gene (HIF1A) are associated with the renal cell carcinoma phenotype.

@article{Ollerenshaw2004PolymorphismsIT,
  title={Polymorphisms in the hypoxia inducible factor-1alpha gene (HIF1A) are associated with the renal cell carcinoma phenotype.},
  author={Martin Ollerenshaw and Thornton L. Page and John C Hammonds and A. G. Demaine},
  journal={Cancer genetics and cytogenetics},
  year={2004},
  volume={153 2},
  pages={
          122-6
        }
}
Hypoxia inducible factor 1 (HIF-1) is a key regulator of the genes involved in the cellular response to hypoxia. HIF consists of alpha and beta subunits, with the alpha subunit being degraded under normoxic conditions and stabilized under hypoxia. We investigated C1772T and G1790A polymorphisms in exon 12 of the HIF gene, which result in an amino acid change from proline 582 to serine and from alanine 588 to threonine, respectively. These polymorphisms are found within the oxygen-dependent… CONTINUE READING
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