Polymorphisms in the human paraoxonase (PON1) promoter.

  title={Polymorphisms in the human paraoxonase (PON1) promoter.},
  author={Victoria H. Brophy and Michele D Hastings and James B Clendenning and Rebecca J. Richter and Gail P. Jarvik and Clement E. Furlong},
  volume={11 1},
Paraoxonase (PON1) is a protein component of high-density lipoprotein (HDL) particles that protects against oxidative damage to both low-density lipoprotein and HDL and detoxifies organophosphorus pesticides and nerve agents. A wide range of expression levels of PON1 among individuals has been observed. We examined the promoter region of PON1 for genetic factors that might affect PON1 activity levels. We conducted a deletion analysis of the PON1 promoter region in transient transfection assays… CONTINUE READING
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