Polymorphisms in the human DNA ligase I gene (LIG1) including a complex GT repeat.

@article{Livak1998PolymorphismsIT,
  title={Polymorphisms in the human DNA ligase I gene (LIG1) including a complex GT repeat.},
  author={Kenneth J Livak and William A. Little and Stephen A. Stack and Tucker A. Patterson},
  journal={Mutation research},
  year={1998},
  volume={406 1},
  pages={
          1-8
        }
}
Sequencing of a human DNA ligase I cDNA clone derived from HeLa cells revealed two unreported differences with the published sequence: a single base change and a three-base deletion. Both differences are in exon 6, and were analyzed by amplifying a segment containing exon 5, intron 6, and exon 6. The first finding was that intron 6 is approximately 2.6 kb in size, not the 1 kb reported in the literature. By sequence analysis of amplified segments, the single-base difference in exon 6 was shown… CONTINUE READING
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