Polymorphisms in the genes ERCC2, XRCC3 and CD3EAP influence treatment outcome in multiple myeloma patients undergoing autologous bone marrow transplantation.

@article{Vangsted2007PolymorphismsIT,
  title={Polymorphisms in the genes ERCC2, XRCC3 and CD3EAP influence treatment outcome in multiple myeloma patients undergoing autologous bone marrow transplantation.},
  author={Annette Juul Vangsted and Peter Gimsing and T W Klausen and Bj\orn A Nex\o and H{\aa}kan Wallin and Tariq O. Andersen and Peter Hokland and S\oren Thue Lillevang and Ulla Vogel},
  journal={International journal of cancer},
  year={2007},
  volume={120 5},
  pages={1036-45}
}
Individual variations in the ability to cope with DNA damage by DNA repair may be essential for the response to chemotherapy, since cancer cells from patients with an effective DNA repair may survive treatment. We have studied the effect on time to treatment failure (TTF) and overall survival (OS) of polymorphism in the DNA repair genes ERCC1, ERCC2 and XRCC3, and in the apoptotic genes PPP1R13L and CD3EAP in 348 patients with multiple myeloma undergoing autologous bone marrow transplantation… CONTINUE READING

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