Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease.

@article{Girelli2000PolymorphismsIT,
  title={Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease.},
  author={Domenico Girelli and Chiara Russo and Paolo Ferraresi and Oliviero Olivieri and Mirko Pinotti and Simonetta Friso and Franco Manzato and Alessandro Mazzucco and Francesco Bernardi and Roberto Corrocher},
  journal={The New England journal of medicine},
  year={2000},
  volume={343 11},
  pages={
          774-80
        }
}
BACKGROUND High plasma levels of coagulation factor VII have been suggested to be predictors of death due to coronary artery disease. Since polymorphisms in the factor VII gene contribute to variations in factor VII levels, such polymorphisms may be associated with the risk of myocardial infarction, which is precipitated by thrombosis. METHODS We studied a total of 444 patients, 311 of whom had severe, angiographically documented coronary atherosclerosis. Of these 311 patients, 175 had… CONTINUE READING
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